in mice going through alcohol withdrawal, the functioning of specific neurons within the mpfc decreased while csf1 gene activity began to increase. previous research in mice suggests that under stress, csf1 production rises in the area of the brain called the mpfc. this can increase feelings of anxiety and depression, as well as induce behavioural deficits linked to alcohol.
“targeting csf1 therefore may be a good strategy for treating aud, and we’re now eager to test that in our preclinical models,” reesha patel, first author of the study, said.
alcohol use on the rise in canada
as of 2018, 19.1 per cent of canadians age 12 and older reported alcohol consumption that classified them as heavy drinkers, according to
statistics canada
. men were more likely to report heavy drinking than women, and the most common age group for both sexes was between 18 and 34 years old.
alcohol is the most commonly used substance in canada, according to the
calgary dream centre
. approximately 21 per cent of people in canada, roughly six million people, will experience a form of substance abuse disorder at some point in their lives.
alcohol use in canada has steadily increased in women since 2013, the calgary dream centre says.
in may of 2020, just after the covid pandemic started, 60 per cent of people reported increased alcohol consumption, according to a study published in the
national library of medicine
.