in a study of more than 10,000 adults with nafld between 2012 and 2021, researchers compared the occurrence of various co-morbid conditions among four weight classes: lean, which consisted of a bmi between 18.5 and 24.9, overweight was 25 to 29.9, class 1 obesity was 30 to 24.9, and class 2-3 obesity was 35 to more than 40.
lean participants had fewer instances of conditions such as cirrhosis, diabetes mellitus, hypertension, and dyslipidemia, when compared to non-lean participants. however, the same lean patients were found to have more occurrences of peripheral vascular disease, cerebrovascular (brain) disease and cardiovascular disease.
“in further analysis, we found that lean patients with nafld also had a significantly higher prevalence of cardiovascular disease, independent of age, sex, race, smoking status, diabetes, hypertension, and dyslipidemia,” wijarnpreecha said.
researchers aren’t exactly sure why lean patients are more susceptible to some conditions than others, but encourage doctors to not overlook nafld patients with lower bmi as they could be facing serious health issues. additional research and studies are planned that will follow the patients long-term to determine if lean patients have a higher risk of developing cardiovascular issues as a result of nafld.
the scientists shared their research as part of
digestive disease week 2022
, a conference in san diego.