“improving clinical diagnostic accuracy is, in my view, the very first thing we need to do in order to find new useful treatments,” beach said.
this impetus led beach and his colleagues to focus on the presence of misfolding alpha-synuclein proteins that form in the brain. researchers have long suspected this protein buildup is key factor in the death of neurons and the ensuing drop in dopamine that eventually triggers the disease. because these proteins simultaneously misfold in other areas of the body as well, beach and his team set out to discover if they could detect them through skin biopsies before the disease manifests itself.
to accomplish this, the researchers examined 50 skin samples — half from parkinson’s sufferers and half from healthy subjects — to see if they could detect the biomarker. by specifically searching for misfolding proteins, they managed to detect the disease in 24 of the 25 parkinson’s patients in the blind study, a remarkable rate of success.
with more than 100,000 canadians
living with parkinson’s today, and roughly 6,600 new diagnoses every year, it’s hard to overstate the benefits of early detection. typically diagnosed around the age of 65 when symptoms become undeniable, the associated
costs
of managing the progressive disease is more than $1.2 billion in canada. monthly medications alone cost the typical canadian patient more than $1,000 per month.