there are four main
clock proteins
that measure our circadian rhythms. the scientists found that the mutation affects a clock protein called cryptochrome. two proteins, called clock and bmal1, work together and turn on the genes for the other two proteins, period and cryptochrome. when combined, they repress the activity of the first pair, “turning themselves off and starting the cycle again,” the researchers say. the mutation causes the “tail” of the cryptochrome protein to get left out.
“the region that gets snipped out actually controls the activity of cryptochrome in a way that leads to a 24-hour clock,” writes study co-author, carrie partch. “without it, cryptochrome binds more tightly and stretches out the length of the clock each day.”
what does that mean for late-sleepers and morning-haters?
“it’s exciting to identify a concrete mechanism in the biological clock that links the biochemistry of this protein to the control of human sleep behaviour,” she says. “this tells us we should be looking for drugs that bind to that pocket and can serve the same purpose as the cryptochrome tail.”
the study shines a light on the complex world of sleep, and provides hope for individuals who shudder at the thought of a breakfast meeting or an early morning yoga class.